Dr Sunil Chopra
BSc MBBS(UK) MRCP(UK)
Consultant Dermatologist |
| Sex |
Male |
| Nationality |
British |
| GMC registration [Full] |
3328774 |
| Society Memberships |
British Medical Association
Royal Society of Medicine
British Association of Dermatology
Medical Defense Union |
| University |
M.B.B.S. University of London, 1990.
Degree of Bachelor of Science [Immunology]
University College London, 1986. |
| Prizes |
National Amulree Prize for the Care of the Aged, 1989.
Primary Health Care Prize 1988.
ICI Elective Award 1988. |
| Research: |
Jan 2005 – To date
Barts & The London & BHR Trusts |
Investigation & clinical trials of nano liposomal encapsulation of Bleomycin for the topical treatment of Basal cell carcinomas and keloids. Research conducted in collaboration with Professor H Navsaria, QMUL. |
| BSc Project: |
“Role of Tumour Necrosis Factor in immunity to Malaria”. |
| Undergraduate |
“Increased General Practitioner consultation rates amongst carers of the elderly.”: prize winning project- National Amulree Prize in care of the elderly: |
| Dermatology Experience |
| DERMATOLOGY |
Consultant Dermatologist Barking, Havering & Redbridge NHS Trust: |
Present Appointment:
1/6/01- present |
Weekly joint Paediatric Dermatology clinic
Weekly phototherapy clinic
Bi monthly Contact Dermatitis clinic
Monthly joint Rheumatology Dermatology clinic
Weekly skin cancer clinic
Honorary Consultant Dermatologist Royal London Hospital
Bimonthly general clinic
Clinical Director & Founder of the London Dermatology Centre, Wimpole Street, London WC1
Founded 2004. Ten thousand patients seen every year by ten Consultant Dermatologists.
Director and founder of SPS Healthcare
This is a company that specializes in developing drugs for delivery in skin disease. The company owns one granted patent and owns one submitted patent. SPS Healthcare collaborates with the following scientists:
Professor Athol Johnson; Professor of Pharmacology Bart’s and the London Medical School.
Professor Steve Brochinni. Professor of Pharmacology, London School of Pharmacy.
Professor Raymond Macallister. Professor of Pharmacology University College London.
Teaching Responsibilities
Course Director Middlesex University Certificate of Dermatology
This is a course to train General Practitioners with a special interest in Dermatology.
Undergraduate student teaching Bart’s and the London Medical School.
Barking & Dagenham General Practitioner Skin Club – Bimonthly teaching.
University College Hospital Accident & Emergency regular teaching of SHOs and registrars
London Dermatology Centre continuing medical education for GPs – Bimonthly teaching.
|
DERMATOLOGY Previous Appointments
1/10/00-31/7/01 |
Senior Clinical Fellow (Post CCST). The Royal London Hospitals NHS Trust & Homerton Hospital NHS Trust |
| 18/10/99-30/9/00 |
Specialist Registrar in Dermatology Royal London Hospitals NHS Trust. |
| 1/6/98-17/10/99 |
Specialist Registrar in Dermatology Ealing & Hammersmith Hospitals & Honorary Research Registrar at Imperial College School of Medicine. |
| 1/10/96-30/5/98 |
Specialist Registrar in Dermatology UCL Hospitals NHS Trust. |
| 1/8/94-30/9/96 |
Research Registrar & Honorary Clinical Registrar in Dermatology to PM Dowd, University College London Medical School. 1994
Thesis entitled " The neurovascular pathophysiology of Raynaud's phenomenon". This involved clinically assessing 27 vibration exposed workers; on site at a British shipyard; for vibration white finger. Each subject’s cutaneous digital vascular responses to injected neuropeptides were assessed using planimetry & laser doppler flow mesurements. All subjects underwent digital cutaneous biopsy & immunostaining for neurovascular peptides. All of the above procedures were carried out on 6 patients with acrocyanosis & perniosis, 6 patients with Raynaud’s phenomenon associated with systemic sclerosis & 6 patients with primary Raynaud’s phenomenon.
The post also involved lecturing medical students, chiropodists, general practitioners & postgraduate students studying for the MRCP part II. I was one of the examiners for the MBBS Jenner Living Dermatology prize & project examiner to the London Foot Hospital. The clinical responsibilities involved one specialist cold related disorders clinic & cover for sick leave for the consultants. |
| 1/2/93- 30/9/93. |
Senior House Officer in Dermatology to Drs TWE Robinson, JJH Gilkes, GM Levene & PM Dowd.
Middlesex Hospital. |
| 1/12/91-31/7/92. |
Senior House Officer in Dermatology to Dr Almeyda. Chase Farm Hospital, Enfield . |
| Previous General Medical Appointments:1/11/93-1/2/94. |
Registrar in Chest Medicine & Intensive Care to Dr T W Higgenbottam & Dr G Park. Addenbrookes Hospital, Cambridge. |
| 1/3/94-31/7/94. |
Registrar in Chest Medicine to Dr J M Schneerson: Papworth Hospital, Cambridge. |
| 1/2/93-1/8/93. |
Senior House Officer in Dermatology & General Medicine: Middlesex Hospital. |
| 1/8/92-31/1/93. |
Senior House Officer in HIV & Genitourinary Medicine: Middlesex Hospital. |
| 1/8/91-31/7/92. |
Senior House Officer Rotation in General Medicine: Chase Farm & Highlands Hospital. |
| 1/2/91-31/7/91. |
Senior House Officer in Accident & Emergency & Intensive Care: Royal Free Hospital. |
| 1/11/90-31/1/91. |
House Physician to M.D.R Sarner & Professor S.G. Bown: University College Hospital. |
| 1/8/90-31/10/90. |
House Physician to A.M Cassoni & M Coulter: Middlesex Hospital. |
| 1/2/90-31/790. |
House Surgeon to I.H.K. Scott: Ipswich General Hospital. February |
| Postgraduate:
August 94-30/9/96 |
“The Neurovascular pathophysiology of Raynaud’s phenomenon”. |
| |
I have used the techniques of quantitative immunohistochemistry & also in-vivo pharmacology to study Raynaud’s phenomenon of different aetiologies. I acquired the necessary skills in immunohistochemistry at the Royal Free Postgraduate Medical School under Professor JM Polak for one year & then established them at UCL. I have also established new techniques in the laboratory and developed an objective test for Vibration White Finger. |
| Patents: |
| Patent Granted |
Patent Number: GB2398495 “A drug delivery preparation comprising at least one anti-tumour drug and a topical carrier for the drug”
S Chopra & K Lau. 22 Aug 2007 |
| Patents Submitted |
Patent filed 2007. Under Review “A topical stable flexible liposomal drug delivery system encapsulating bleomycin” S Chopra. |
| Publications in preparation: |
| |
ET Anthony, S Kantaria, G Moir, S Davison, S Chopra. The stability of liposomal bleomycin and its penetration in human skin. Submitted to British Journal of Dermatology
Case report on 3 patients with verrucae using liposomal bleomycin.
A Case Report of the use of topical liposomal Bleomycin to treat a nodular BCC.
The formulation of a stable flexible liposome
The penetration of liposomal mithramycin in human skin explants
Apoptosis or Necrosis? How does skin die in the presence of liposomal bleomycin |
| Publications: |
| |
Papagiorgiou P, Chopra S et al. The treatment of Rosacea. Accepted for publication British Journal of Dermatology March 2008
Anthony ET, Kantaria S, Moir G and S Chopra. The penetrative abilities of liposomal mithramycin in explanted keloids. Accepted for publication Clinical and Experimental Dermatology March 2008.
Anthony E, Syed M, Vaiude P, Chopra S, Davies K, Nduka C, Shibu M, Moir GC. A 6 year review of the clinical relevance of steroid therapy in keloid management. International Proceedings of the 7th European Trauma Congress. May 2006. Accepted for publication.
Lau KG, Hattori Y, Chopra S, O'Toole EA, Storey A, Nagai T, et al. Ultra-deformable liposomes containing bleomycin: in vitro stability and toxicity on human cutaneous keratinocyte cell lines. Int J Pharm 2005;300(1-2):4-12
Kuttikat A, Saeed T, Chopra B, Chopra S, Chakravarty K. Nasal Wegener's and skin sarcoid-a rare combination of two granulomatous diseases. Clin Rheumatol 2005:1-3
Freedman TLD, editor. Malignant melanoma following irradiation for tinea capitis. European Academy of Dermatology and Venereology; 2004 Nov 2004. Blackwell Publishing.
Ameen M, Chopra S, Darvay A, Acland K, Chu AC. Erythema gyratum repens and acquired ichthyosis associated with transitional cell carcinoma of the kidney. Clin Exp Dermatol 2001;26(6):510-2.
Bull HA, Leslie TA, Chopra S, Dowd PM. Expression of nerve growth factor receptors in cutaneous inflammation. Br J Dermatol 1998;139(5):776-83.
S. Chopra, N.J. Levell, G. Cowley & J.J.H. Gilkes. Systemic Corticosteroids in the phenytoin hypersensitivity syndrome.
Br J of Dermatol 1996; 134: 1109-1112.
S. Chopra, M.M.L Martins & PM. Dowd. Increased expression of nerve growth factor, p75 nerve growth factor receptor & GAP 43 in systemic sclerosis: BSID proceedings. Br J of Dermatol 1996; 134: 592.
S. Chopra, M.M. L Martins & P. M. Dowd. Comparison of the expression of nerve growth factor, p75 nerve growth factor receptor, trk A & GAP 43 in systemic sclerosis & vibration white finger.
SID proceedings J Invest Dermatol 1996, 106: 821.
N.J Levell, A.P. Bewley, S. Chopra, D. Churchill, P. French, R. Miller & J.J.H. Gilkes. Bacillary angiomatosis with cutaneous & oral lesions in an HIV-infected patient from the U.K.
Br J of Dermatol 1995;132: 113-115.
S. Chopra, H. A. Bull & Pauline M. Dowd. Nerve Growth Factor & its receptors in relation to GAP 43 & cutaneous nerve fibre depletion in Vibration White Finger. In preparation.
S. Chopra, H.A Bull & Pauline M. Dowd. Nerve Growth Factor & its receptor p75 & GAP 43 are upregulated in the Raynaud’s phenomenon of Systemic sclerosis but not in Primary Raynaud’s phenomenon. In preparation.
Pauline M Dowd, P. Goldsmith, S.Chopra, H.A Bull & JC Foreman. Cutaneous responses to endothelin-1 & histamine in patients with vibration white finger. J Invest Dermatol. 1999 Feb; 110(2): 127-31
H.A Bull, T.A Leslie, S.Chopra. Expression of nerve growth factor receptors in cutaneous inflammation. Br J Dermatol 1998 Nov, 139 (5): 776-83
S. Chopra, S.Munn & A.C Chu. B-cell lymphoma presenting as Langerhans cell histiocytosis. BAD proceedings Br J of Dermatol. 1999, 141 supplement 55. 128
S.Chopra, P.Human & A.C Chu. Antihistamines in atopic dermatitis. CME Bulletin Dermatology.1999 (2); 1, 16-19. |
| Postgraduate Book Chapters |
| |
F Vega-Lopez & S. Chopra. Manson’s 21stth Edition ‘Textbook of Infectious Disease’
S.Chopra & A.C Chu. “Treatment of Cancer” Eds Pat Price & Karol Sikora. 4th Edition. Arnold 2002. Chapter 38 ‘Non-Melanoma Skin Cancer’. PP 799-830
S. Chopra & F Vega-Lopez. “The Granulomatous disorders” Eds: D.Geraint James & Alimuddin Zumla. Cambridge University Press 1999. Chapter 33-Skin Granulomas in Clinical Practice. PP 485-525 |
| Book chapter in preparation: |
F Vega-Lopez & S. Chopra. Manson’s 22nd Edition ‘Textbook of Infectious Disease”; chapter revision. |
| Presentations at Scientific Meetings
International |
| |
Anthony ET, Vaiude PN, Syed M, Chopra S, Rattan B, H Navsaria The use of skin explants and primary cells in testing nano liposomal topical keloid treatments; Tissue Engineering, Wurzburg, Germany May 2006
Anthony ET, Vaiude PN, Chopra S, Syed M, Rattan B, Leigh I, H Navsaria. Treatment of keloids with liposomes. Scars 2006, Montpellier, France 29 March 2006
P Timpanides, S.Chopra, P.M Dowd , H.E Kemp & J.G Gawkroger. Transplacental transfer of anti tyrosinase IgG antibodies causing vitiligo in a newborn baby. American Academy of Dermatology. San-Francisco-March 2000
A.C Chu, S.Chopra & M Amheen. Calipitriol in vitiligo an open study. European Academy od Dermatology & Veneorology- Amsterdam, 29 September-4 October 1999
S.Datta, S.Chopra & PM Dowd. Vascular hyporeactivity in acrocyanosis & perniosis. American Academy of Dermatology Annual Conference May 23-28 1999-Chicago
H. A. Bull, S. Chopra, PM. Dowd. Nerve Growth Factor & its receptors & GAP 43 in cutaneous inflammation & vasospasm.
55th Annual Meeting of American Academy of Dermatology, 21-26th March 1997 - San Francisco.
S. Chopra, H. A. Bull & Pauline M. Dowd. Diltiazem therapy partially reverses the cutaneous nerve fibre depletion of Vibration White Finger. 25th Anniversary Meeting European Society for Dermatological Research, 28th September-1st October 1996 - Amsterdam.
S. Chopra, M.M. L Martins & P. M. Dowd. Comparison of the expression of nerve growth factor, p75 nerve growth factor receptor, trk A & GAP 43 in systemic sclerosis & vibration white finger.
Society of Investigative Dermatology, 1-5th May 1996 - Washington DC. |
| National Presentations |
| |
Anthony ET, Vaiude PN, Syed M, Chopra S, H Navsaria; Nano-liposomal Bleomycin: The future for BCC treatment; Brit Assoc of Plastic Surgery summer meeting, Sheffield; 12 July 2006– Poster
Anthony ET, Chopra S, Moir GC, Navsaria HN. Emerging Nano-liposomal technology for BCC treatment. West Midlands National Plastics & Burns Surgery Meeting; October 2005
Anthony ET, Lau K , Trigiante G, Chopra S, Moir GC, Navsaria HN. Bleomycin in an Ultra Deformable Liposome. William Harvey Day, Great Hall, St Bartholomew’s Hospital, Queen Mary, University of London; October 2005.
Anthony ET, Chopra S, Moir GC, Navsaria HN. Emerging Nano-liposomal technology for BCC treatment. West Midlands National Plastics & Burns Surgery Meeting; October 2005.
Anthony ET, Lau K , Trigiante G, Chopra S, Moir GC, Navsaria HN. Bleomycin in an Ultra Deformable Liposome. William Harvey Day, Great Hall, St Bartholomew’s Hospital, Queen Mary, University of London; October 2005.
H. A. Bull, S. Chopra & Pauline M Dowd. Neuropeptides, Vasospasm & cutaneous inflammation.
45th Annual Symposium on the biology of skin, 20-24th May 1996 - Snowmass, Colorado.
S. Chopra, M.M.L Martins & Pauline M. Dowd. Increased expression of nerve growth factor, p75 nerve growth receptor & GAP 43 in systemic sclerosis.
British Society of Investigative Dermatology, 28 -29th March 1996 - Glasgow
S. Chopra, S.Munn & A.C Chu. B-cell lymphoma presenting as Langerhans cell histiocytosis. British Association of Dermatology 79th Annual Meeting, 29 June – 3 July 1999- Edinburgh
S.Chopra, V. Exarchou & A.C Chu. Digital videomicroscopy in the follow up of pigmented skin lesions. British Association of Dermatology 79th Annual Meeting, 29 June – 3 July 1999- Edinburgh |
| International Poster presentations |
Anthony ET, Vaiude PN, Chopra S, Syed M, Rattan B, Leigh I, H Navsaria. Treatment of keloids with liposomes. Scars 2006, Montpellier, France 29 March 2006 |
| Presentations at Royal Society of Medicine Section of Dermatology |
| |
S. Chopra & J.J.H. Gilkes. Phenytoin hypersensitivity syndrome. 15th June 1995
S.Chopra & P.M Dowd. Primary erthromelalgia. 17th April 1997
S.Chopra & R.Y Yu. Spontaneous graft versus host disease 17th April 1997
S.Chopra & R.Y Yu. Vesicular eruption in a case of Churg Strauss vasculitis CPC. January 1998
S.Chopra & R.Groves. A case of hereditary anetoderma. March 1998
S.Chopra & N.J Lowe Transplacental transfer of antityrosinase IgG antibody causing vitiligo in a newborn baby. March 1998
S.Chopra & R. Russell Jones. Cutaneous vasculitis & hepatitis C infection. February 1999
S.Chopra & A.C Chu. CD30+ lymphoma occurring in a patient with a diagnosis of psoriasis. November 1999 |
| Presentations at Grand Rounds |
| |
Epidermodysplasia verruciformis UCL Hospitals November 1997
Primary erythromelalgia UCL Hospitals February 1998
Phenytoin hypersensitivity syndrome. Hammmersmith Hospital July 1998
Churg Strauss syndrome presenting as blindness. Hammmersmith Hospital February 1999
Bullous pemphigoid associated with malignancy. Hammmersmith Hospital April 1999
B-Cell Lymphoma presenting as Langerhans histiocytosis Hammmersmith Hospital July 1999 |
| St John’s Registrar meetings |
Presented on 2 occasions - October 1998 & June 1999 |
| Courses Organised |
UCL Hospitals NHS Trust – Annual Teaching Course for general practitioners – lectured on two occasions.
Hammersmith Hospitals NHS Trust – Annual Practise Nurses Course – lectured on two occasions. |
| Courses Attended: |
| |
Skin Biology Course – Cambridge 1996
Novartis Management Course – February 1998
Hammersmith Hospitals Skin Histopathology Course – May 1999
|
| Medical School Activities: |
Elected the first University College & Middlesex School of Medicine Students Union president 1986-87. |
